Bonfili L., Cecarini V., Cuccioloni M., Angeletti M., Berardi S., Scarpona S., Rossi G., Eleuteri A.M.
Affiliation
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino (MC), Italy.
Abstract
The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the treatment of CNS-associated disorders. In this study, we explored the properties of a probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer’s disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated with SLAB51 and the effects on protein oxidation, neuronal antioxidant defence and repair systems were monitored, with the particular focus on the role of SIRT1-related pathways. We demonstrated that SLAB51 markedly reduced oxidative stress in AD mice brain by activating SIRT1-dependent mechanisms, thus representing a promising therapeutic adjuvant in AD treatment.
Mol Neurobiol. 2018 Oct;55(10):7987-8000. doi: 10.1007/s12035-018-0973-4.